hrp0082p1-d3-188 | Pituitary | ESPE2014

Butyrate Stimulates GH Secretion From Rat Anterior Pituitary Cells Via the G-Protein-Coupled Receptors GPR41 and 43

Miletta Maria Consolata , Petkovic Vibor , Eble Andree , Ammann Roland , Fluck Christa E , Mullis Primus E

Background: Butyrate is a short-chain fatty acid closely related to the ketone body β-hydroxybutyrate (BHB) considered as the major source of energy during prolonged exercise. During fasting, when the liver switches to fatty acid oxidation, a rise in serum GH occurs concomitantly with the accumulation of BHB and short chain fatty acids (SCFA) acetate, propionate and butyrate. Interactions between GH, ketone body and SCFA during the metabolic adaptation to fasting are poor...